Feline Panleukopenia I. Pathogenesis in Germfree and Specific Pathogen-Free Cats
- 1 January 1977
- journal article
- research article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 14 (1), 79-88
- https://doi.org/10.1177/030098587701400110
Abstract
Germfree and specific pathogen-free cats were inoculated with panleukopenia virus. Total leucocyte counts decreased significantly in both germfree and specific pathogen-free cats. Clinical illness was not seen in any germfree cat. Specific pathogen-free cats had anorexia and slight diarrhea 5-6 days after inoculation. None of the cats died. Both germfree and specific pathogen-free cats had thymic involution. No other gross lesions were seen. Tissues for histological virus isolation and immunofluorescence studies were taken daily from days 2 through 6 after inoculation. Virus-infected cells and lesions of panleukopenia were seen in the small intestine of both germfree and specific pathogen-free cats. The incidence of virus-infected cells and lesions was greater in specific pathogen-free cats than in germfree cats.Keywords
This publication has 3 references indexed in Scilit:
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- The Comparative Pathogenesis of Some Enteric Diseases. Based on Cases Presented at the 22nd Annual Seminar of the American College of Veterinary PathologistsVeterinary Pathology, 1973
- Abstracts of Intestinal Pathology Cases: From The 22nd Annual Seminar American College of Veterinary Pathologists Denver, Colorado December 2–4, 1971Veterinary Pathology, 1972