The lysosome as a cellular centre for signalling, metabolism and quality control
Top Cited Papers
- 2 January 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 21 (2), 133-142
- https://doi.org/10.1038/s41556-018-0244-7
Abstract
Long known as terminal degradation stations, lysosomes have emerged as sophisticated signalling centres that govern cell growth, division and differentiation. Lysosomes interface physically and functionally with other organelles, and the master regulator mechanistic target of rapamycin complex 1 kinase is activated on lysosomes in response to nutrient and growth factor inputs. Lysosomes also enable autophagy, a 'self-eating' process essential for quality control and stress adaptation. Faulty execution of lysosomal growth and catabolic programmes drives cancer, neurodegeneration and age-related diseases.Keywords
This publication has 156 references indexed in Scilit:
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1Cell, 2012
- Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular ClearanceDevelopmental Cell, 2011
- FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during AgingCell, 2010
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1Molecular Cell, 2010
- With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in AgingCell Metabolism, 2010
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino AcidsCell, 2010
- mTOR Mediates Wnt-Induced Epidermal Stem Cell Exhaustion and AgingCell Stem Cell, 2009
- The yeast lysosome-like vacuole: Endpoint and crossroadsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell GrowthCell Metabolism, 2008
- A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in gliomaCancer Cell, 2006