A Putative Prokaryote Voltage-Gated Ca2+ Channel with Only One 6TM Motif per Subunit
- 2 March 2001
- journal article
- Published by Elsevier BV in Biochemical and Biophysical Research Communications
- Vol. 281 (3), 741-746
- https://doi.org/10.1006/bbrc.2001.4408
Abstract
Until now, voltage-gated Ca(2+) channel proteins have been found only in eukaryotes. Here we report that a gene recently discovered in the eubacterium Bacillus halodurans codes for a protein closely related to eukaryotic Ca(2+) channels, but that has only one 6-transmembrane-segement (6TM) motif, instead of four, in its pore-forming subunit. This is supported by the comparison of consensus sequences, which, along with the patterns of residue conservation, indicates a similar structure in the membrane to voltage-gated K(+) channels. From this we hypothesize that Ca(2+) channels originally evolved in bacteria, and that the specific eubacteria protein highlighted here is an ideal candidate for structure determination efforts.Keywords
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