Recent trends in the birth prevalence of Down syndrome in China: impact of prenatal diagnosis and subsequent terminations
- 14 October 2014
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 35 (4), 311-318
- https://doi.org/10.1002/pd.4516
Abstract
Objective This study aims to analyze recent trends in Down syndrome (DS) prevalence in China and evaluate the impact of prenatal diagnosis and subsequent terminations. Design A birth defects surveillance-based retrospective study was adopted. Methods On the basis of the 1996 to 2011 surveillance data for DS from Chinese Birth Defects Monitoring Network, we examined the total prevalence ratio (TPR), perinatal prevalence ratio (PPR) and percentages of prenatally identified cases and of terminations by periods (before and after 2003), birth area, gender and maternal-age classifications. Results Down syndrome TPR was 3.05 per 10 000 births during 2003 to 2011, with significant differences between urban–rural, gender and maternal-age groups. DS PPR during 1996 to 2011 was 1.99 per 10 000, presenting an increasing trend till 2003 but a decreasing tendency since then. The proportion of DS diagnosed prenatally increased from 7.55% during 1996 to 2002 to 47.70% during 2003 to 2011, varying by birth area and maternal age. During 2003 to 2011, the high termination rate led to 55% reduction in the overall DS PPR and 62% and 36% decreases in urban and rural PPRs. Conclusion The important reduction in the PPR suggests that current strategies in China for the prenatal screening and diagnosis of DS are effective. However, significant urban–rural variations in TPR and PPR indicate an urgent need to strengthen prenatal care for DS in rural regions. © 2014 John Wiley & Sons, Ltd.Funding Information
- National Natural Science Foundation of China (81072375)
This publication has 24 references indexed in Scilit:
- Prenatal diagnosis of Down syndrome: a systematic review of termination rates (1995–2011)Prenatal Diagnosis, 2012
- Time trends in oral clefts in Chinese newborns: Data from the Chinese National Birth Defects Monitoring NetworkBirth Defects Research Part A: Clinical and Molecular Teratology, 2009
- Live birth prevalence of Down syndrome in Tottori, Japan, 1980–1999American Journal of Medical Genetics Part A, 2008
- Preliminary study into the economic burden of Down syndrome in ChinaBirth Defects Research Part A: Clinical and Molecular Teratology, 2007
- The four ages of Down syndromeEuropean Journal of Public Health, 2006
- The evolving national birth prevalence of Down syndrome in Taiwan. A study on the impact of second-trimester maternal serum screeningPrenatal Diagnosis, 2005
- A population‐based evaluation of the impact of antenatal screening for Down's syndrome in France, 1981–2000BJOG: An International Journal of Obstetrics and Gynaecology, 2004
- Inference for Contingency TablesPublished by Wiley ,2002
- Trends in prenatal diagnosis of Down syndrome and other autosomal trisomies in Scotland 1990 to 1994, with associated cytogenetic and epidemiological findingsGenetic Epidemiology, 1999
- Cytogenetic and epidemiological findings in Down syndrome, England and Wales 1989 to 1993. National Down Syndrome Cytogenetic Register and the Association of Clinical Cytogeneticists.Journal of Medical Genetics, 1996