Time estimation in Parkinson's disease and degenerative cerebellar disease
- 2 July 2008
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in NeuroReport
- Vol. 19 (10), 1055-1058
- https://doi.org/10.1097/wnr.0b013e328303b7b9
Abstract
With functional MRI, we recently identified fronto-cerebellar activations in predicting time to reach a target and basal ganglia activation in velocity estimation, that is, small interval assessment. We now tested these functions in patients with Parkinson's disease (PD) and degenerative cerebellar ataxia. They watched a ball that repeatedly appeared, moved, and disappeared. Velocity, stop locations, and predicted target locations as well as time to reach a target were indicated. Compared with controls, PD patients showed impaired velocity estimation (momentary mode) whereas temporal prediction was selectively impaired in cerebellar ataxia patients. The latter highlights feed-forward processing within fronto-cerebellar circuitry. Impaired velocity estimation in PD fits the concept of a basal ganglia clock function.Keywords
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