Associated Loss of Fat-free Mass and Bone Mineral Density in Chronic Obstructive Pulmonary Disease
- 15 December 2004
- journal article
- Published by American Thoracic Society in American Journal of Respiratory and Critical Care Medicine
- Vol. 170 (12), 1286-1293
- https://doi.org/10.1164/rccm.200406-754oc
Abstract
We hypothesized that in patients with chronic obstructive pulmonary disease, loss of fat-free mass (FFM) and loss of bone mineral density (BMD) were related to (1) each other and may be clinically inapparent, (2) urinary markers of cellular and bone collagen protein breakdown, and (3) severity of lung disease. Eight-one patients and 38 healthy subjects underwent dual-energy X-ray absorptiometry to determine body composition and BMD. Urinary protein breakdown markers, inflammatory mediators, and their soluble receptors were determined. Thirty-three patients had a low fat-free mass index (kg/m(2)), 17 of whom had a normal body mass index. Thirty-two percent of patients (13% of healthy subjects) had osteoporosis at the hip or lumbar spine. The marker of cellular protein breakdown was elevated in patients and related to lung disease severity and body composition. The marker of bone collagen breakdown was greater in patients with osteoporosis. Inflammatory mediators were elevated in patients. Loss of FFM and loss of BMD were related, occurred commonly, and could be subclinical in patients with chronic obstructive pulmonary disease. Loss of both was greatest with severe lung disease. Increased excretion of cellular and bone collagen protein breakdown products in those with low FFM and BMD indicates a protein catabolic state in these patients.Keywords
This publication has 55 references indexed in Scilit:
- Altered tissue distribution in adults with cystic fibrosisThorax, 2003
- Catabolic/Anabolic Balance and Muscle Wasting in Patients With COPDChest, 2003
- Bedside methodsversusdual energy X‐ray absorptiometry for body composition measurement in COPDEuropean Respiratory Journal, 2002
- Osteoporosis in Elderly Men and Women: Effects of Dietary Calcium, Physical Activity, and Body Mass IndexJournal of Bone and Mineral Research, 2000
- Loss of bone mineral in patients with cachexia due to chronic heart failureThe American Journal of Cardiology, 1999
- Pseudouridine and 1-Ribosylpyridin-4-One-3-Carboxamide (PCNR) Serum Concentrations in Human Immunodeficiency Virus Type 1-Infected Patients Are Independent Predictors for AIDS ProgressionThe Journal of Infectious Diseases, 1996
- Muscle Undergoes Atrophy in Association with Increase of Lysosomal Cathepsin Activity in Interleukin-6 Transgenic MouseBiochemical and Biophysical Research Communications, 1995
- Body composition and exercise performance in patients with chronic obstructive pulmonary disease.Thorax, 1991
- Local and Systemic Factors in the Pathogenesis of OsteoporosisNew England Journal of Medicine, 1988
- Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factorsNature, 1986