Human Immunodeficiency Virus Types 1 and 2 Exhibit Comparable Sensitivities to Zidovudine and Other Nucleoside Analog Inhibitors In Vitro
- 1 January 2008
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 52 (1), 329-332
- https://doi.org/10.1128/aac.01004-07
Abstract
Using an indicator cell assay that directly quantifies viral replication, we show that human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2, respectively) exhibit similar sensitivities to 3′-azido-3′-deoxythymidine (zidovudine) as well as other nucleoside analog inhibitors of reverse transcriptase. These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection.Keywords
This publication has 27 references indexed in Scilit:
- Natural Polymorphisms in the Human Immunodeficiency Virus Type 2 Protease Can Accelerate Time to Development of Resistance to Protease InhibitorsAntimicrobial Agents and Chemotherapy, 2007
- Trypanin, a Component of the Flagellar Dynein Regulatory Complex, Is Essential in Bloodstream Form African TrypanosomesPLoS Pathogens, 2006
- Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse TranscriptaseJournal of Virology, 2006
- Why Do HIV-1 and HIV-2 Use Different Pathways to Develop AZT Resistance?PLoS Pathogens, 2006
- Susceptibility to protease inhibitors in HIV-2 primary isolates from patients failing antiretroviral therapyJournal of Antimicrobial Chemotherapy, 2006
- Purifying Selection Masks the Mutational Flexibility of HIV-1 Reverse TranscriptasePublished by Elsevier BV ,2004
- Equal Plasma Viral Loads Predict a Similar Rate of CD4+T Cell Decline in Human Immunodeficiency Virus (HIV) Type 1– and HIV‐2–Infected Individuals from Senegal, West AfricaThe Journal of Infectious Diseases, 2002
- Comparison of the Sensitivities of Primary Isolates of HIV Type 2 and HIV Type 1 to Antiviral Drugs and Drug CombinationsAIDS Research and Human Retroviruses, 1994
- Reduced Rate of Disease Development After HIV-2 Infection as Compared to HIV-1Science, 1994
- HIV-1 Reverse Transcription A Termination Step at the Center of the GenomeJournal of Molecular Biology, 1994