World distribution of factor V Leiden
- 1 October 1995
- journal article
- research article
- Published by Elsevier BV in The Lancet
- Vol. 346 (8983), 1133-1134
- https://doi.org/10.1016/s0140-6736(95)91803-5
Abstract
We have analysed 3380 chromosomes (1690 unrelated individuals) from twenty-four populations for the presence of factor V Leiden, an important risk factor in venous thromboembolism. The allele frequency in 618 Europeans was 4.4%, with the highest prevalence among Greeks (7%). It was 0.6% in Asia Minor. Factor V Leiden was not found in any of 1600 chromosomes from Africa, Southeast Asia, Australasia, and the Americas. This distribution may partly explain the rarity of thromboembolic disease in these populations. The high prevalence in Europeans suggests that screening for this mutation should be considered in some circumstances.Keywords
This publication has 9 references indexed in Scilit:
- Mutation in the Gene Coding for Coagulation Factor V and the Risk of Myocardial Infarction, Stroke, and Venous Thrombosis in Apparently Healthy MenNew England Journal of Medicine, 1995
- High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance) [see comments]Blood, 1995
- 11 The molecular genetics of familial venous thrombosisBailliere's Clinical Haematology, 1994
- Activated protein C resistance as an additional risk factor for thrombosis in protein C-deficient familiesBlood, 1994
- Mutation in blood coagulation factor V associated with resistance to activated protein CNature, 1994
- Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia StudyThe Lancet, 1993
- Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.Proceedings of the National Academy of Sciences of the United States of America, 1993
- Epidemiology of coagulation disordersBailliere's Clinical Haematology, 1992
- Varicose Veins, Deep Vein Thrombosis, and Haemorrhoids: Epidemiology and Suggested AetiologyBMJ, 1972