Mycobacterium ulceransCytotoxicity in an Adipose Cell Model
Open Access
- 1 November 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (11), 7182-7186
- https://doi.org/10.1128/iai.69.11.7182-7186.2001
Abstract
An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis uponMycobacterium ulceransinfection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors inM.ulceransmay be involved in Buruli ulcer pathogenesis.Keywords
This publication has 14 references indexed in Scilit:
- Detection of Phospholipase C in Nontuberculous Mycobacteria and Its Possible Role in Hemolytic ActivityJournal of Clinical Microbiology, 2001
- Necrosis of Lung Epithelial Cells during Infection withMycobacterium tuberculosisIs Preceded by Cell PermeationInfection and Immunity, 2000
- Cytocidal and Apoptotic Effects of the ClyA Protein from Escherichia coli on Primary and Cultured Monocytes and MacrophagesInfection and Immunity, 2000
- Biochemical and Genetic Evidence for Phospholipase C Activity inMycobacterium ulceransInfection and Immunity, 2000
- Serologic Response to Culture Filtrate Antigens of Mycobacterium ulcerans during Buruli Ulcer DiseaseEmerging Infectious Diseases, 2000
- AMycobacterium ulceransToxin, Mycolactone, Causes Apoptosis in Guinea Pig Ulcers and Tissue Culture CellsInfection and Immunity, 2000
- Growth and cytotoxic activity byMycobacterium ulceransin protein-free mediaFEMS Microbiology Letters, 1999
- The inhibitory action of Mycobacterium ulcerans soluble factor on monocyte/T cell cytokine production and NF-kappa B function.1999
- Out of Africa: observations on the histopathology of Mycobacterium ulcerans infection.Journal of Clinical Pathology, 1993
- Immunosuppressive Properties of the Soluble Toxin from Mycobacterium ulceransThe Journal of Infectious Diseases, 1988