Genomic Rearrangement of the mec Regulator Region Mediated by Insertion of IS 431 in Methicillin-Resistant Staphylococci
Open Access
- 1 January 2001
- journal article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 45 (1), 335-338
- https://doi.org/10.1128/aac.45.1.335-338.2001
Abstract
Genomic diversification of the mec regulator region mediated by IS 431 was investigated for clinical isolates of methicillin-resistant staphylococci. A single rearranged form of the mecR1 gene due to IS 431 insertion was detected in the three staphylococcal species, while another type of mecR1 truncation with IS 431 and an IS 431 located downstream of mecI were found only in Staphylococcus haemolyticus . Genetic differentiation of IS 431 and staphylococcal isolates suggested transmission of mec DNA with IS 431 -mediated rearrangement among different staphylococcal species.Keywords
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