The Left Ventral Occipito-Temporal Response to Words Depends on Language Lateralization but Not on Visual Familiarity
Open Access
- 14 August 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in Cerebral Cortex
- Vol. 20 (5), 1153-1163
- https://doi.org/10.1093/cercor/bhp175
Abstract
The sensitivity of the left ventral occipito-temporal (vOT) cortex to visual word processing has triggered a considerable debate about the role of this region in reading. One popular view is that the left vOT underlies the perceptual expertise needed for rapid skilled reading. Because skilled reading breaks down when words are presented in a visually unfamiliar format, we tested this hypothesis by analyzing vOT responses to horizontally presented words (familiar format) and vertically presented words (unfamiliar format). In addition, we compared the activity in participants with left and right cerebral dominance for language generation. Our results revealed 1) that the vOT activity during reading is lateralized to the same side as the inferior frontal activity during word generation, 2) that vertically and horizontally presented words triggered the same amount of activity in the vOT of the dominant hemisphere, but 3) that there was significantly more activity for vertically presented words in the vOT of the nondominant hemisphere. We suggest that the reading-related activity in vOT reflects the integration of general perceptual processes with language processing in the anterior brain regions and is not limited to skilled reading in the familiar horizontal format.Keywords
This publication has 52 references indexed in Scilit:
- On the Functional Neuroanatomy of Visual Word Processing: Effects of Case and Letter DevianceJournal of Cognitive Neuroscience, 2009
- Selective activation around the left occipito‐temporal sulcus for words relative to pictures: Individual variability or false positives?Human Brain Mapping, 2008
- The evolution of the arcuate fasciculus revealed with comparative DTINature Neuroscience, 2008
- Neural correlates of orthographic and phonological consistency effects in childrenHuman Brain Mapping, 2007
- The effect of viewpoint on perceived visual roughnessJournal of Vision, 2007
- The role of the posterior fusiform gyrus in readingJournal of Cognitive Neuroscience, 2006
- The pro and cons of labelling a left occipitotemporal region: “the visual word form area”NeuroImage, 2004
- A network of occipito-temporal face-sensitive areas besides the right middle fusiform gyrus is necessary for normal face processingBrain, 2003
- The anatomy of language: contributions from functional neuroimagingJournal of Anatomy, 2000
- Word recognition in the human inferior temporal lobeNature, 1994