Molecular Genetics of Circadian Rhythms in Mammals
- 1 March 2000
- journal article
- review article
- Published by Annual Reviews in Annual Review of Neuroscience
- Vol. 23 (1), 713-742
- https://doi.org/10.1146/annurev.neuro.23.1.713
Abstract
Recent gene discovery approaches have led to a new era in our understanding of the molecular basis of circadian oscillators in animals. A conserved set of genes in Drosophila and mammals (Clock, Bmal1, Period, and Timeless) provide a molecular framework for the circadian mechanism. These genes define a transcription-translation–based negative autoregulatory feedback loop that comprises the core elements generating circadian rhythmicity. This circadian core provides a focal point for understanding how circadian rhythms arise, how environmental inputs entrain the oscillatory system, and how the circadian system regulates its outputs. The addition of molecular genetic approaches to the existing physiological understanding of the mammalian circadian system provides new opportunities for understanding this basic life process.Keywords
This publication has 97 references indexed in Scilit:
- Immortal Time: Circadian Clock Properties of Rat Suprachiasmatic Cell LinesScience, 1999
- Role of the CLOCK Protein in the Mammalian Circadian MechanismScience, 1998
- A Screen for Genes Induced in the Suprachiasmatic Nucleus by LightScience, 1998
- cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix–Loop–Helix/PAS Protein (BMAL1) and Identification of Alternatively Spliced Variants with Alternative Translation Initiation Site UsageBiochemical and Biophysical Research Communications, 1997
- Cloning and Selective Expression in Brain and Kidney of ARNT2 Homologous to the Ah Receptor Nuclear Translocator (ARNT)Biochemical and Biophysical Research Communications, 1996
- Putative Human Blue-Light Photoreceptors hCRY1 and hCRY2 Are FlavoproteinsBiochemistry, 1996
- Circadian Rhythm in Membrane Conductance Expressed in Isolated NeuronsScience, 1993
- Basic Local Alignment Search ToolJournal of Molecular Biology, 1990
- Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleusNeuron, 1990
- Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levelsNature, 1990