High Endemicity of Human T-Cell Lymphotropic Virus Type 1 Among Pregnant Women in Peru
- 15 August 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 42 (5), 604-609
- https://doi.org/10.1097/01.qai.0000221680.52563.d5
Abstract
Summary: Human T-cell lymphotropic virus type 1(HTLV-1) is associated with adult T-cell leukemia, tropical spastic paraparesis, and other immune-mediated diseases. There are reports of groups with high prevalences of HTLV-1 infection in Peru, but there is limited knowledge of the epidemiology of infection or which routes of infection are most important. We studied 2492 women presenting to a large maternity hospital in Lima for prenatal, delivery, or abortion services. HTLV-1 seropositivity was confirmed in 42 women (1.7%; 95% confidence interval, 1.2-2.2). Seroprevalence increased with age but did not vary by region of birth or recency of migration to Lima. Age greater than 30 years and sexual intercourse before 20 years of age were strongly and independently associated with infection. History of abortion and history of transfusion were of borderline significance. Women whose male partner had a characteristic that might be a marker for risk of sexually transmitted infections were also more likely to be infected. HTLV-1 is common among Peruvians throughout the country and is maintained by a low level of neonatally acquired infection that is amplified by sexual transmission. In addition to screening of the blood supply, instituted in 1997, programs designed to reduce neonatal and sexual transmission should be effective.Keywords
This publication has 27 references indexed in Scilit:
- A Prospective Study of Sexual Transmission of Human T Lymphotropic Virus (HTLV)–I and HTLV‐IIThe Journal of Infectious Diseases, 2005
- Clinical Characteristics of Patients in Peru with Human T Cell Lymphotropic Virus Type 1–Associated Tropical Spastic ParaparesisClinical Infectious Diseases, 2004
- Determinants and prevalence of HIV infection in pregnant Peruvian womenAIDS, 2003
- La experiencia de Perú con un programa nacional de bancos de sangreRevista Panamericana de Salud Pública, 2003
- Virus Markers Associated with Vertical Transmission of Human T Lymphotropic Virus Type 1 in JamaicaClinical Infectious Diseases, 2002
- Human T-Cell Lymphotropic Virus Type 1 Infection Among Pregnant Women in Northeastern BrazilJAIDS Journal of Acquired Immune Deficiency Syndromes, 2001
- Human T Cell Lymphotropic Virus Type I Infection among Female Sex Workers in PeruThe Journal of Infectious Diseases, 1994
- Heterosexual Transmission of Human T Cell Leukemia/Lymphoma Virus Type I among Married Couples in Southwestern Japan: An Initial Report from the Miyazaki Cohort StudyThe Journal of Infectious Diseases, 1993
- Sexual transmission of human T‐lymphotropic virus type I in Peruvian prostitutesJournal of Medical Virology, 1992
- Seroepidemiologic Studies Of Human T-cell leukemia/lymphoma virus type I in JamaicaInternational Journal of Cancer, 1985