Targeting Immune Modulators in Glioma While Avoiding Autoimmune Conditions
Open Access
- 13 July 2021
- Vol. 13 (14), 3524
- https://doi.org/10.3390/cancers13143524
Abstract
Communication signals and signaling pathways are often studied in different physiological systems. However, it has become abundantly clear that the immune system is not self-regulated, but functions in close association with the nervous system. The neural–immune interface is complex; its balance determines cancer progression, as well as autoimmune disorders. Immunotherapy remains a promising approach in the context of glioblastoma multiforme (GBM). The primary obstacle to finding effective therapies is the potent immunosuppression induced by GBM. Anti-inflammatory cytokines, induction of regulatory T cells, and the expression of immune checkpoint molecules are the key mediators for immunosuppression in the tumor microenvironment. Immune checkpoint molecules are ligand–receptor pairs that exert inhibitory or stimulatory effects on immune responses. In the past decade, they have been extensively studied in preclinical and clinical trials in diseases such as cancer or autoimmune diseases in which the immune system has failed to maintain homeostasis. In this review, we will discuss promising immune-modulatory targets that are in the focus of current clinical research in glioblastoma, but are also in the precarious position of potentially becoming starting points for the development of autoimmune diseases like multiple sclerosis.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (CRC1292 TP09, CRC1292 TP04, SCHM 2159/4-1)
This publication has 187 references indexed in Scilit:
- Nectin-2 is a potential target for antibody therapy of breast and ovarian cancersMolecular Cancer, 2013
- Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1Nature Immunology, 2012
- Cell Surface Signaling Molecules in the Control of Immune Responses: A Tide ModelImmunity, 2011
- Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environmentProceedings of the National Academy of Sciences of the United States of America, 2010
- The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicityProceedings of the National Academy of Sciences of the United States of America, 2009
- A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DCEuropean Journal of Immunology, 2009
- Nectins and nectin-like molecules: roles in contact inhibition of cell movement and proliferationNature Reviews Molecular Cell Biology, 2008
- TGFβ in CancerCell, 2008
- Dysregulated T cell expression of TIM3 in multiple sclerosisThe Journal of Experimental Medicine, 2006
- Radiotherapy plus Concomitant and Adjuvant Temozolomide for GlioblastomaNew England Journal of Medicine, 2005