MULTIPLE SYMMETRIC LIPOMATOSIS (LAUNOIS‐BENSAUDE SYNDROME): EFFECT OF ORAL SALBUTAMOL
- 1 November 1987
- journal article
- Published by Wiley in Clinical Endocrinology
- Vol. 27 (5), 601-606
- https://doi.org/10.1111/j.1365-2265.1987.tb01190.x
Abstract
A 65-year-old Kenyan Asian developed rapidly progressive multiple symmetrical lipomatosis over 8 years. Noradrenaline infusion showed a normal response of plasma free fatty acids. In-vitro studies of the lipomatous tissue demonstrated intact lipolytic activities with a normal rate of free fatty acids release and cyclic AMP accumulation with or without isoprenaline and fenoterol stimulation. A clinical trial of oral salbutamol, a beta 2-agonist, was performed with significant therapeutic effect. The body fat mass showed a reversal of the rapid progression while on the treatment, associated with an increase in the resting metabolic rate.Keywords
This publication has 10 references indexed in Scilit:
- Multiple Symmetric LipomatosisMedicine, 1984
- Adrenergic regulation of adipocyte metabolism.Journal of Lipid Research, 1983
- Adrenergic regulation of fat‐cell lipolysis in multiple symmetric lipomatosisEuropean Journal of Clinical Investigation, 1982
- MULTIPLE SYMMETRIC LIPOMATOSIS (LAUNOIS-BENSAUDE SYNDROME) - ADIPOSE TISSUE INSENSITIVITY TO CYCLIC AMPJournal of Clinical Endocrinology & Metabolism, 1979
- Total body potassium calibrations for normal and obese subjects in two types of whole body counterPhysics in Medicine & Biology, 1979
- Multiple symmetric lipomatosis: a defect in adrenergic-stimulated lipolysis.JCI Insight, 1977
- A more sensitive and stable colorimetric determination of free fatty acids in bloodJournal of Lipid Research, 1977
- A simple direct assay for cyclic amp in plasma and other biological samples using an improved competitive protein binding techniqueClinica Chimica Acta; International Journal of Clinical Chemistry, 1974
- Benign symmetric lipomatosis: Functional sympathetic denervation of adipose tissue and possible hypertrophy of brown fatMetabolism, 1974
- Familial multiple lipomatosisThe American Journal of Surgery, 1951