The diverse functional LINCs of the nuclear envelope to the cytoskeleton and chromatin
Open Access
- 5 June 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Chromosoma
- Vol. 122 (5), 415-429
- https://doi.org/10.1007/s00412-013-0417-x
Abstract
The nuclear envelope (NE) is connected to the different types of cytoskeletal elements by linker of nucleoskeleton and cytoskeleton (LINC) complexes. LINC complexes exist from yeast to humans, and have preserved their general architecture throughout evolution. They are composed of SUN and KASH domain proteins of the inner and the outer nuclear membrane, respectively. These SUN–KASH bridges are used for the transmission of forces across the NE and support diverse biological processes. Here, we review the function of SUN and KASH domain proteins in various unicellular and multicellular species. Specifically, we discuss their influence on nuclear morphology and cytoskeletal organization. Further, emphasis is given on the role of LINC complexes in nuclear anchorage and migration as well as in genome organization.Keywords
This publication has 139 references indexed in Scilit:
- LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN ProteinsCell, 2012
- Shaping the nucleus: Factors and forcesJournal of Cellular Biochemistry, 2012
- Accumulation of the Inner Nuclear Envelope Protein Sun1 Is Pathogenic in Progeric and Dystrophic LaminopathiesCell, 2012
- Orientation and function of the nuclear–centrosomal axis during cell migrationCurrent Opinion in Cell Biology, 2011
- Role of the nuclear envelope in genome organization and gene expressionWires Systems Biology and Medicine, 2010
- Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and SynapsisCell, 2009
- A Network of Nuclear Envelope Membrane Proteins Linking Centromeres to MicrotubulesCell, 2008
- Meiotic Chromosomes Move by Linkage to Dynamic Actin Cables with Transduction of Force through the Nuclear EnvelopeCell, 2008
- Nuclear migration during retinal developmentBrain Research, 2008
- Post-embryonic cell lineages of the nematode, Caenorhabditis elegansDevelopmental Biology, 1977