Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis
- 12 November 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 24 (12), 1804-1808
- https://doi.org/10.1038/s41591-018-0238-9
Abstract
We report the first case series of immune checkpoint inhibitors (ICI)-associated colitis successfully treated with fecal microbiota transplantation, with reconstitution of the gut microbiome and a relative increase in the proportion of regulatory T-cells within the colonic mucosa. These preliminary data provide evidence that modulation of the gut microbiome may abrogate ICI-associated colitis.This publication has 30 references indexed in Scilit:
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