Analysis of a non-synonymous single nucleotide polymorphism of the human diamine oxidase gene (ref. SNP ID: rs1049793) in patients with Crohn's disease
- 1 January 2009
- journal article
- research article
- Published by Informa UK Limited in Scandinavian Journal of Gastroenterology
- Vol. 44 (10), 1207-1212
- https://doi.org/10.1080/00365520903171250
Abstract
To analyse the possible influence of a non-synonymous single nucleotide polymorphism (SNP) of the histamine-degrading enzyme diamine oxidase (DAO) on genetic susceptibility to Crohn's disease (CD). In this prospective, case-control study, 210 unrelated Caucasian consecutive CD patients were recruited at the Inflammatory Bowel Disease Unit of a single tertiary centre (Hospital Clínico San Carlos) in Madrid, Spain. A total of 261 healthy volunteers from the same geographic area were also recruited and matched with patients. Both cases and controls were analysed for the presence of a non-synonymous SNP (rs1049793) of DAO using amplification-restriction procedures of the genotype obtained in a blood sample. No significant differences were found in the distribution of carriers of the non-synonymous SNP of DAO between CD patients and controls (OR 1.2 (95% CI 0.9-1.6; p=0.3)). Nor were any differences found between carriers and non-carriers of the non-synonymous SNP in demographic characteristics, phenotypes, complications or treatment of CD. The study of a non-synonymous SNP (rs1049793) of DAO does not seem to be of use in assessing susceptibility to CD, either as a marker of disease activity or as a marker of clinical behaviour in patients with the disease.Keywords
This publication has 17 references indexed in Scilit:
- Histamine pharmacogenomicsPharmacogenomics, 2009
- Improved analytical sensitivity reveals the occurrence of gender-related variability in diamine oxidase enzyme activity in healthy individualsClinical Biochemistry, 2007
- Genetic variability of human diamine oxidase: occurrence of three nonsynonymous polymorphisms and study of their effect on serum enzyme activityPharmacogenetics and Genomics, 2007
- Methylhistamine in Crohn's disease (CD): Increased production and elevated urine excretion correlates with disease activityInflammation Research, 2000
- Mucosal Histamine Content and Histamine Secretion in Crohn’s Disease, Ulcerative Colitis and Allergic EnteropathyInternational Archives of Allergy and Immunology, 1995
- Intestinal mast cell responses in idiopathic inflammatory bowel diseaseDigestive Diseases and Sciences, 1993
- Human kidney amiloride-binding protein: cDNA structure and functional expression.Proceedings of the National Academy of Sciences of the United States of America, 1990
- The jejunal secretion of histamine is increased in active Crohn's diseaseGastroenterology, 1990
- Classification of Inflammatory Bowel DiseaseScandinavian Journal of Gastroenterology, 1989
- Crohn's disease: Transmission electron microscopic studiesHuman Pathology, 1980