Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin
Top Cited Papers
- 4 April 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 556 (7700), 255-258
- https://doi.org/10.1038/s41586-018-0010-9
Abstract
Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health1. Bats have been recognized as one of the most important reservoirs for emerging viruses and the transmission of a coronavirus that originated in bats to humans via intermediate hosts was responsible for the high-impact emerging zoonosis, severe acute respiratory syndrome (SARS)2,3,4,5,6,7,8,9,10. Here we provide virological, epidemiological, evolutionary and experimental evidence that a novel HKU2-related bat coronavirus, swine acute diarrhoea syndrome coronavirus (SADS-CoV), is the aetiological agent that was responsible for a large-scale outbreak of fatal disease in pigs in China that has caused the death of 24,693 piglets across four farms. Notably, the outbreak began in Guangdong province in the vicinity of the origin of the SARS pandemic. Furthermore, we identified SADS-related CoVs with 96–98% sequence identity in 9.8% (58 out of 591) of anal swabs collected from bats in Guangdong province during 2013–2016, predominantly in horseshoe bats (Rhinolophus spp.) that are known reservoirs of SARS-related CoVs. We found that there were striking similarities between the SADS and SARS outbreaks in geographical, temporal, ecological and aetiological settings. This study highlights the importance of identifying coronavirus diversity and distribution in bats to mitigate future outbreaks that could threaten livestock, public health and economic growth.Keywords
This publication has 25 references indexed in Scilit:
- Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirusPLoS Pathogens, 2017
- A New Bat-HKU2–like Coronavirus in Swine, China, 2017Emerging Infectious Diseases, 2017
- Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome CoronavirusJournal of Virology, 2016
- Identification of Diverse Alphacoronaviruses and Genomic Characterization of a Novel Severe Acute Respiratory Syndrome-Like Coronavirus from Bats in ChinaJournal of Virology, 2014
- Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptorNature, 2013
- Complete genome sequence of bat coronavirus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest of the genomeVirology, 2007
- Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe batsProceedings of the National Academy of Sciences of the United States of America, 2005
- Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirusNature, 2003
- A Novel Coronavirus Associated with Severe Acute Respiratory SyndromeThe New England Journal of Medicine, 2003
- Identification of a Novel Coronavirus in Patients with Severe Acute Respiratory SyndromeThe New England Journal of Medicine, 2003