Tumour-released exosomes and their implications in cancer immunity
- 12 October 2007
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell Death & Differentiation
- Vol. 15 (1), 80-88
- https://doi.org/10.1038/sj.cdd.4402237
Abstract
Tumour cells release vesicular structures, defined as microvesicles or exosomes, carrying a large array of proteins from their originating cell. The expression of antigenic molecules recognized by T cells has originally suggested a role for these organelles as a cell-free antigen source for anticancer vaccines. However, recent evidence shows that tumour exosomes may also exert a broad array of detrimental effects on the immune system, ranging from apoptosis in activated antitumour T cells to impairment of monocyte differentiation into dendritic cells and induction of myeloid suppressive cells. Immunosuppressive exosomes of tumour origin can be found in neoplastic lesions and sera from cancer patients, implying a potential role of this pathway in in vivo tumour progression. Through the expression of molecules involved in angiogenesis promotion, stromal remodelling, delivery of signalling pathways through growth factor/receptor transfer, chemoresistance and genetic intercellular exchange, tumour exosomes could represent a versatile tool for moulding host environment. Hence, their secretion by neoplastic cells may in the future become a novel pathway to target for therapeutic intervention in cancer patients.Keywords
This publication has 72 references indexed in Scilit:
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicityBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
- Immunosuppressive Strategies that are Mediated by Tumor CellsAnnual Review of Immunology, 2007
- Vincristine Induces Dramatic Lysosomal Changes and Sensitizes Cancer Cells to Lysosome-Destabilizing SiramesineCancer Research, 2007
- Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?Nature Clinical Practice Oncology, 2006
- Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomasProceedings of the National Academy of Sciences, 2006
- The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans The Journal of cell biology, 2006
- Tumour-derived exosomes and their role in cancer-associated T-cell signalling defectsBritish Journal of Cancer, 2005
- Mechanisms and functional significance of tumour-induced dendritic-cell defectsNature Reviews Immunology, 2004
- Exosomes: endosomal-derived vesicles shipping extracellular messagesCurrent Opinion in Cell Biology, 2004