Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis
- 31 July 2011
- journal article
- editorial
- Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene
- Vol. 105 (7), 361-363
- https://doi.org/10.1016/j.trstmh.2011.04.003
Abstract
Every year in endemic countries, several million individuals are given anthelminthic drugs in the context of preventive chemotherapy programmes for morbidity control of schistosomiasis and soil-transmitted helminthiasis. The capacity to evaluate accurately the efficacy of the drugs used as well as the health impact produced by treatment is of utmost importance for appropriate planning and implementation of these interventions. Cure rate is an indicator of drug efficacy that was originally developed for assessing the clinical efficacy of antibiotics on selected bacterial diseases. Over time, this indicator has also been widely applied to anthelminthic drugs and consequently used to monitor and evaluate preventive chemotherapy interventions. In the author's opinion, however, measurement of cure rate provides information of limited usefulness in the context of helminth control programmes. The present article analyses the peculiarities of helminth infections and those of the drugs used in preventive chemotherapy, explaining the reasons why the cure rate is not an adequate indicator in this specific public health context.Keywords
This publication has 8 references indexed in Scilit:
- Comparing Diagnostic Accuracy of Kato-Katz, Koga Agar Plate, Ether-Concentration, and FLOTAC for Schistosoma mansoni and Soil-Transmitted HelminthsPLoS Neglected Tropical Diseases, 2010
- A free weekly iron-folic acid supplementation and regular deworming program is associated with improved hemoglobin and iron status indicators in Vietnamese womenBMC Public Health, 2009
- Diagnostic dilemmas in helminthology: what tools to use and when?Trends in Parasitology, 2009
- Efficacy of Current Drugs Against Soil-Transmitted Helminth InfectionsJAMA, 2008
- LOW EFFICACY OF MEBENDAZOLE AGAINST HOOKWORM IN VIETNAM: TWO RANDOMIZED CONTROLLED TRIALSThe American Journal of Tropical Medicine and Hygiene, 2007
- Control of Schistosoma mekongi in Cambodia: results of eight years of control activities in the two endemic provinces.Transactions of the Royal Society of Tropical Medicine and Hygiene, 2007
- Interventions for treating schistosomiasis mansoniPublished by Wiley ,1999
- Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the Southern Region of Mali, West AfricaTransactions of the Royal Society of Tropical Medicine and Hygiene, 1999