Reproducibility of continuous arterial spin labeling perfusion MRI after 7 weeks
- 11 April 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in Magnetic Resonance Materials in Physics, Biology and Medicine
- Vol. 20 (2), 103-115
- https://doi.org/10.1007/s10334-007-0073-3
Abstract
Background Continuous arterial spin labeling (CASL) is a non-invasive technique for the measurement of cerebral blood flow (CBF). The aim of the present study was to examine the reproducibility of CASL measurements and its suitability to consistently detect differences between groups, regions, and resting states. Materials and methods Thirty-eight healthy subjects (19 female) were examined at 1.5 T on two measurement occasions that were seven weeks apart. Resting CBF was measured with eyes open and eyes closed. Results In different regions of interest (ROIs) the repeatability estimates varied between 9 and 19 ml/100 g/min. There were no significant mean differences between occasions in all ROIs (P > 0.05). Greater CBF in the eyes-open than in the eyes-closed state was consistently present in the primary and secondary visual areas. Furthermore, CBF was consistently greater in the right than in the left hemisphere (P < 0.05) and differed between lobes and between arterial territories (P < 0.001). Finally, we consistently observed greater CBF in women than in men (P < 0.001). Conclusion This study demonstrates the suitability of CASL to consistently detect differences between groups, regions, and resting states even after seven weeks. This emphasizes its usefulness for longitudinal designs.This publication has 57 references indexed in Scilit:
- Quantitative perfusion measurements using pulsed arterial spin labeling: Effects of large region‐of‐interest analysisJournal of Magnetic Resonance Imaging, 2005
- Coupling of cerebral blood flow and oxygen consumption during physiological activation and deactivation measured with fMRINeuroImage, 2004
- Eyes open and eyes closed as rest conditions: impact on brain activation patternsNeuroImage, 2004
- Comparison of Arterial Spin-Labeling Techniques and Dynamic Susceptibility-Weighted Contrast-Enhanced MRI in Perfusion Imaging of Normal Brain TissueInvestigative Radiology, 2003
- Perfusion‐based functional magnetic resonance imagingConcepts in Magnetic Resonance Part A, 2003
- Regional cerebral blood flow pattern in normal young and aged volunteers: a99mTc-HMPAO SPET studyEuropean Journal of Nuclear Medicine and Molecular Imaging, 1996
- Magnetic resonance imaging of the brain: Blood partition coefficient for water: Application to spin‐tagging measurement of perfusionJournal of Magnetic Resonance Imaging, 1996
- Improved Assessment of Significant Activation in Functional Magnetic Resonance Imaging (fMRI): Use of a Cluster‐Size ThresholdMagnetic Resonance in Medicine, 1995
- Reproducibility of Resting Cerebral Blood Flow Measurements with H215O Positron Emission Tomography in HumansJournal of Cerebral Blood Flow & Metabolism, 1993
- Normal Distribution of Regional Cerebral Blood Flow Measured by Dynamic Single-Photon Emission TomographyJournal of Cerebral Blood Flow & Metabolism, 1986