Inhibition of polyamine accumulation and deoxyribonucleic acid synthesis in regenerating rat liver
- 15 August 1976
- journal article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 158 (2), 485-488
- https://doi.org/10.1042/bj1580485
Abstract
Repeated injections of 1,3-diaminopropane into rats after partial hepatectomy caused a repression-type inhibiton of liver ornithine decarboxylase (EC 4.1.1.17) and totally prevented the marked increases in liver putrescine and spermidine concentrations that normally occur in response to partial hepatectomy. The inhibition of polyamine synthesis by diaminopropane was accompanied by a profound decrease (about 80%) in the synthesis of DNA in the regenerating rat liver without any changes in the synthesis of RNA and total liver protein.This publication has 24 references indexed in Scilit:
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