Recruitment of Polycomb group complexes and their role in the dynamic regulation of cell fate choice
- 1 November 2009
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 136 (21), 3531-3542
- https://doi.org/10.1242/dev.033902
Abstract
Polycomb group (PcG) protein complexes dynamically define cellular identity through the regulation of key developmental genes. Important advances in the PcG field have come from genome-wide mapping studies in a variety of tissues and cell types that have analyzed PcG protein complexes, their associated histone marks and putative mechanisms of PcG protein recruitment. We review how these analyses have contributed to our understanding of PcG protein complex targeting to chromatin and consider the importance of diverse PcG protein complex composition for gene regulation. Finally, we focus on the dynamics of PcG protein complex action during cell fate transitions and on the implications of histone modifications for cell lineage commitment.Keywords
This publication has 116 references indexed in Scilit:
- Ezh2 Orchestrates Gene Expression for the Stepwise Differentiation of Tissue-Specific Stem CellsCell, 2009
- H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage CommitmentCell, 2008
- Dynamic Regulation of Nucleosome Positioning in the Human GenomeCell, 2008
- The Histone H3 Lysine-27 Demethylase Jmjd3 Links Inflammation to Inhibition of Polycomb-Mediated Gene SilencingCell, 2007
- Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAsCell, 2007
- High-Resolution Profiling of Histone Methylations in the Human GenomeCell, 2007
- Genome Regulation by Polycomb and Trithorax ProteinsCell, 2007
- Transcription of bxd Noncoding RNAs Promoted by Trithorax Represses Ubx in cis by Transcriptional InterferenceCell, 2006
- Control of Developmental Regulators by Polycomb in Human Embryonic Stem CellsCell, 2006
- A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem CellsCell, 2006