Mechanosensitive TRPV4 channels stabilize VE-cadherin junctions to regulate tumor vascular integrity and metastasis
- 27 October 2018
- journal article
- research article
- Published by Elsevier BV in Cancer Letters
- Vol. 442, 15-20
- https://doi.org/10.1016/j.canlet.2018.07.042
Abstract
No abstract availableKeywords
Funding Information
- National Institutes of Health (R15CA202847, R01HL119705)
This publication has 26 references indexed in Scilit:
- TRPV4 channel activation selectively inhibits tumor endothelial cell proliferationScientific Reports, 2015
- Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapyOncogene, 2015
- Angiogenic responses are enhanced in mechanically and microscopically characterized, microbial transglutaminase crosslinked collagen matrices with increased stiffnessActa Biomaterialia, 2013
- Vascular endothelial-cadherin and vascular stabilityCurrent Opinion in Hematology, 2012
- Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forcesAmerican Journal of Physiology-Cell Physiology, 2011
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin SignalingCell, 2009
- Regulation of vascular integrityJournal of Molecular Medicine, 2009
- Calcification of Multipotent Prostate Tumor EndotheliumCancer Cell, 2008
- Openings between Defective Endothelial Cells Explain Tumor Vessel LeakinessThe American Journal of Pathology, 2000
- Vascular endothelial–cadherin is an important determinant of microvascular integrityinvivoProceedings of the National Academy of Sciences of the United States of America, 1999