Gender Differences in Schizophrenia and First-Episode Psychosis: A Comprehensive Literature Review
Top Cited Papers
Open Access
- 8 April 2012
- journal article
- review article
- Published by Hindawi Limited in Schizophrenia Research and Treatment
- Vol. 2012, 1-9
- https://doi.org/10.1155/2012/916198
Abstract
Recent studies have begun to look at gender differences in schizophrenia and first-episode psychosis in an attempt to explain the heterogeneity of the illness. However, a number of uncertainties remain. This paper tries to summarize the most important findings in gender differences in schizophrenia and first-psychosis episodes. Several studies indicate that the incidence of schizophrenia is higher in men. Most of the studies found the age of onset to be earlier in men than in women. Findings on symptoms are less conclusive, with some authors suggesting that men suffer more negative symptoms while women have more affective symptoms. Premorbid functioning and social functioning seem to be better in females than males. However, cognitive functioning remains an issue, with lack of consensus on differences in neuropsychological profile between women and men. Substance abuse is more common in men than women with schizophrenia and first-episode psychosis. In terms of the disease course, women have better remission and lower relapse rates. Lastly, there is no evidence of specific gender differences in familial risk and obstetric complications. Overall, gender differences have been found in a number of variables, and further study in this area could help provide useful information with a view to improving our care of these patients.Keywords
This publication has 109 references indexed in Scilit:
- Cannabis Use and the Course of Schizophrenia: 10-Year Follow-Up After First HospitalizationAmerican Journal of Psychiatry, 2010
- Differences among Men and Women with Schizophrenia: A Study of US and Indian SamplesPsychiatry Investigation, 2010
- Association of Pre-Onset Cannabis, Alcohol, and Tobacco Use With Age at Onset of Prodrome and Age at Onset of Psychosis in First-Episode PatientsAmerican Journal of Psychiatry, 2009
- Metabolic profile of antipsychotic-naive individuals with non-affective psychosisThe British Journal of Psychiatry, 2009
- Sex differences in schizophrenia and other psychotic disorders: a 20-year longitudinal study of psychosis and recoveryComprehensive Psychiatry, 2008
- Gender differences in symptoms, functioning and social support in patients at ultra-high risk for developing a psychotic disorderSchizophrenia Research, 2008
- Antipsychotic-induced hyperprolactinaemia, hypogonadism and osteoporosis in the treatment of schizophreniaJournal of Psychopharmacology, 2008
- Antipsychotic-Induced HyperprolactinaemiaDrugs, 2004
- Sexual dysfunction in patients taking conventional antipsychotic medicationThe British Journal of Psychiatry, 2002
- First-episode Schizophrenia: I. Early Course ParametersSchizophrenia Bulletin, 1996