PENGARUH MINUMAN DIPERKAYA CINNULIN TERHADAP MDA DAN SENYAWA INFLAMASI PLASMA PENDERITA DMT2
Open Access
- 1 June 2016
- journal article
- Published by Department of Food Science and Technology, IPB University (Bogor Agricultural University) in Jurnal Teknologi dan Industri Pangan
- Vol. 27 (1), 51-58
- https://doi.org/10.6066/jtip.2016.27.1.51
Abstract
Cinnamon has been used as a traditional treatment for thousands of years. Aqueous cinnamon extract namely cinnulin is known to have positive effects on type-2 diabetes mellitus (T2DM). We aimed to study the effect of cinnulin enriched drink rich in polyphenols on plasma malondialdehyde (MDA), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) in T2DM patients. 255 mg of cinnulin was mixed with tea extract into a 2.5 gram of instant drink with alumunium foil as the packaging material. A single blind study were performed on 33 respondents with T2DM from Dramaga District. Respondents were divided into three groups, i.e. group given cinnulin enriched drink (1), instant tea drink (2), and none of the products (control) (3). Group 1 and 2 were assigned to drink two sachetsof the products a day for 5 weeks. The MDA content of all groups remain unchanged after treatment although slightly increased (Wilcoxon, P>0.050) and no differences between groups was observed (P>0.050) suggesting that high phenolic content in the producst cause a reverse effect. Both inflammation marker (IL-6 and COX-2) decreased significantly for groups given cinnulin enriched drink and instant tea, whereas there is a significant increase for IL-6 and a significant decrease for COX-2 in control group. These results conclude that cinnulin enriched drink can be used as an antiinflammation drink for T2DM.Keywords
This publication has 22 references indexed in Scilit:
- Effects of Cinnamon, Cardamom, Saffron, and Ginger Consumption on Markers of Glycemic Control, Lipid Profile, Oxidative Stress, and Inflammation in Type 2 Diabetes PatientsThe Review of Diabetic Studies, 2014
- Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-NonenalOxidative Medicine and Cellular Longevity, 2014
- Oxidative Stress in Diabetes Mellitus and the Role Of Vitamins with Antioxidant ActionsPublished by IntechOpen ,2013
- Tea and DiabetesPublished by Elsevier BV ,2013
- Diabetes and Hypertension: Is There a Common Metabolic Pathway?Current Atherosclerosis Reports, 2012
- Cinnamon Polyphenol Extract Affects Immune Responses by Regulating Anti- and Proinflammatory and Glucose Transporter Gene Expression in Mouse Macrophages , ,3Journal of Nutrition, 2008
- Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytesArchives of Biochemistry and Biophysics, 2007
- Tea, obesity, and diabetesMolecular Nutrition & Food Research, 2006
- Interleukin-6 and DiabetesDiabetes, 2005
- Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological ActivityJournal of Agricultural and Food Chemistry, 2003