Mammalian piRNAs
- 1 January 2014
- journal article
- Published by Taylor & Francis Ltd in Spermatogenesis
- Vol. 4 (1), e27889
- https://doi.org/10.4161/spmg.27889
Abstract
Piwi-interacting RNAs (piRNAs) are a distinct class of small non-coding RNAs specifically expressed in the germline of many species. They are most notably required for transposon silencing. Loss of piRNAs results in defects in germ cell development, and thus, infertility. Most studies of piRNAs have been done in Drosophila, but much progress has also been made on piRNAs in the germline of mammals and other species in the past few years. This review provides a summary of our current knowledge of the biogenesis and functions of piRNAs during mouse spermatogenesis and discusses challenges in the mammalian piRNA field.Keywords
This publication has 113 references indexed in Scilit:
- Small RNA in the nucleus: the RNA-chromatin ping-pongCurrent Opinion in Genetics & Development, 2012
- MITOPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse GermlineDevelopmental Cell, 2011
- piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid SignalingDevelopmental Cell, 2011
- A Broadly Conserved Pathway Generates 3′UTR-Directed Primary piRNAsCurrent Biology, 2009
- Mili Interacts with Tudor Domain-Containing Protein 1 in Regulating SpermatogenesisCurrent Biology, 2009
- Tdrd6 Is Required for Spermiogenesis, Chromatoid Body Architecture, and Regulation of miRNA ExpressionCurrent Biology, 2009
- Small RNAs as Guardians of the GenomeCell, 2009
- MicroRNAs: Target Recognition and Regulatory FunctionsCell, 2009
- Mouse Maelstrom, a Component of Nuage, Is Essential for Spermatogenesis and Transposon Repression in MeiosisDevelopmental Cell, 2008
- PRG-1 and 21U-RNAs Interact to Form the piRNA Complex Required for Fertility in C. elegansMolecular Cell, 2008