Idiopathic granulomatous and necrotising inflammatory disorders of the canine central nervous system: a review and future perspectives
- 25 February 2010
- journal article
- review article
- Published by Wiley in Journal of Small Animal Practice
- Vol. 51 (3), 138-149
- https://doi.org/10.1111/j.1748-5827.2009.00823.x
Abstract
Granulomatous meningoencephalomyelitis, necrotizing meningoencephalitis, and necrotizing leukoencephalitis are common inflammatory conditions of the canine central nervous system. Although each disease has unique histopathological features, these canine disorders collectively seem to be aberrant immune responses directed against the central nervous system. A review of the neurological signs and general neurodiagnostic approach to canine meningoencephalitis is followed by an overview of the specific clinical and neuropathological features of granulomatous meningoencephalomyelitis, necrotizing meningoencephalitis, and necrotizing leukoencephalitis. The aetiopathogenesis of each disorder is explored including potential genetic, immunological, and environmental factors along with the current and prospective immunomodulatory therapies for meningoencephalitis.Keywords
This publication has 64 references indexed in Scilit:
- Heritability and transmission analysis of necrotizing meningoencephalitis in the PugResearch in Veterinary Science, 2009
- Magnetic Resonance Imaging Characteristics of Necrotizing Meningoencephalitis in Pug DogsJournal of Veterinary Internal Medicine, 2009
- Infection-Triggered Familial or Recurrent Cases of Acute Necrotizing Encephalopathy Caused by Mutations in a Component of the Nuclear Pore, RANBP2American Journal of Human Genetics, 2009
- Comparison of magnetic resonance imaging sequences in dogs with multi‐focal intracranial diseaseJournal of Small Animal Practice, 2008
- MAGNETIC RESONANCE IMAGING FINDINGS IN HISTOLOGICALLY CONFIRMED PUG DOG ENCEPHALITISVeterinary Radiology & Ultrasound, 2008
- Epidemiology of Necrotizing Meningoencephalitis in Pug DogsJournal of Veterinary Internal Medicine, 2008
- Necrotising encephalitis in a French bulldogJournal of Small Animal Practice, 2007
- Cerebellar Focal Granulomatous Meningoencephalitis in a Dog: Clinical Findings and MR ImagingJournal of Veterinary Medicine Series A, 2004
- Hepatotoxicity Associated with CCNU (Lomustine) Chemotherapy in DogsJournal of Veterinary Internal Medicine, 2004
- Detection of louping ill virus in formalin-fixed, paraffin wax-embedded tissues of mice, sheep and a pig by the avidin-biotin-complex immunoperoxidase techniqueVeterinary Record, 1994