Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations
Open Access
- 10 January 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 3 (1), 621
- https://doi.org/10.1038/ncomms1632
Abstract
The genes of the major histocompatibility complex are the most polymorphic genes in vertebrates, with more than 1,000 alleles described in human populations. How this polymorphism is maintained, however, remains an evolutionary puzzle. Major histocompatibility complex genes have a crucial function in the adaptive immune system by presenting parasite-derived antigens to T lymphocytes. Because of this function, varying parasite-mediated selection has been proposed as a major evolutionary force for maintaining major histocompatibility complex polymorphism. A necessary prerequisite of such a balancing selection process is rapid major histocompatibility complex allele frequency shifts resulting from emerging selection by a specific parasite. Here we show in six experimental populations of sticklebacks, each exposed to one of two different parasites, that only those major histocompatibility complex alleles providing resistance to the respective specific parasite increased in frequency in the next host generation. This result demonstrates experimentally that varying parasite selection causes rapid adaptive evolutionary changes, thus facilitating the maintenance of major histocompatibility complex polymorphism.This publication has 34 references indexed in Scilit:
- Plasmodium relictuminfection and MHC diversity in the house sparrow (Passer domesticus)Proceedings. Biological sciences, 2010
- Antagonistic coevolution with parasites maintains host genetic diversity: an experimental testProceedings. Biological sciences, 2010
- Multiple reciprocal adaptations and rapid genetic change upon experimental coevolution of an animal host and its microbial parasiteProceedings of the National Academy of Sciences of the United States of America, 2010
- How pathogens drive genetic diversity: MHC, mechanisms and misunderstandingsProceedings. Biological sciences, 2010
- MHC‐based mate choice combines good genes and maintenance of MHC polymorphismMolecular Ecology, 2009
- RSCA genotyping of MHC for high-throughput evolutionary studies in the model organism three-spined stickleback Gasterosteus aculeatusBMC Evolutionary Biology, 2009
- Simple approach to reduce PCR artefact formation leads to reliable genotyping of MHC and other highly polymorphic loci — Implications for evolutionary analysisGene, 2008
- Lifetime reproductive success is maximized with optimal major histocompatibility complex diversityProceedings. Biological sciences, 2008
- The IMGT/HLA databaseNucleic Acids Research, 2008
- Between-year variation of MHC allele frequencies in great reed warblers: selection or drift?Journal of Evolutionary Biology, 2004