Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs
- 28 April 2010
- journal article
- Published by Royal Society of Chemistry (RSC) in Organic & Biomolecular Chemistry
- Vol. 8 (12), 2777-2783
- https://doi.org/10.1039/c001772h
Abstract
The addition of various nucleophiles to a vinyl 1,2,4-oxadiazole is described. Following optimisation, individual protocols tuned for the use of each specific class of reagent have been developed to allow the installation of nitrogen, sulfur, oxygen, and carbon nucleophiles, and leading to the preparation of a series of compounds containing the pharmaceutically important oxadiazole motif.This publication has 31 references indexed in Scilit:
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