Pyroptotic cell death defends against intracellular pathogens
Top Cited Papers
- 16 April 2015
- journal article
- review article
- Published by Wiley in Immunological Reviews
- Vol. 265 (1), 130-142
- https://doi.org/10.1111/imr.12287
Abstract
Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase‐1 induces the activation and secretion of the two prominent pro‐inflammatory cytokines, interleukin‐1β (IL‐1β) and IL‐18. Second, either caspase‐1 or caspase‐11 can trigger a form of lytic, programmed cell death called pyroptosis. Pyroptosis operates to remove the replication niche of intracellular pathogens, making them susceptible to phagocytosis and killing by a secondary phagocyte. However, aberrant, systemic activation of pyroptosis in vivo may contribute to sepsis. Emphasizing the efficiency of inflammasome detection of microbial infections, many pathogens have evolved to avoid or subvert pyroptosis. This review focuses on molecular and morphological characteristics of pyroptosis and the individual inflammasomes and their contribution to defense against infection in mice and humans.Keywords
Funding Information
- NIH (DK007737, AI097518)
This publication has 124 references indexed in Scilit:
- Rapid induction of inflammatory lipid mediators by the inflammasome in vivoNature, 2012
- Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1Nature, 2012
- Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in MiceImmunity, 2011
- NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for ColitisCell, 2011
- IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus InfectionCell Host & Microbe, 2011
- Generation of aListeriavaccine strain by enhanced caspase-1 activationEuropean Journal of Immunology, 2011
- Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine ProcessingCell Host & Microbe, 2010
- Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenesJournal of Clinical Immunology, 2010
- A Yersinia Effector Protein Promotes Virulence by Preventing Inflammasome Recognition of the Type III Secretion SystemCell Host & Microbe, 2010
- Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage CytosolCell Host & Microbe, 2010