Endogenous inhibitor of prostaglandin synthetase
Open Access
- 1 November 1977
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 270 (5632), 32-36
- https://doi.org/10.1038/270032a0
Abstract
Mammalian serum and plasma contain an endogenous inhibitor of prostaglandin synthetase (EIPS). Human plasma fractions rich in EIPS show anti-inflammatory activity in vivo. In rats, glucocorticoids raise EIPS activity of plasma and serum. These findings suggest the existence of a natural mechanism of controlling prostaglandin synthesis, possibly related to corticosteroid action.Keywords
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