Venlafaxine for the Control of Hot Flashes: Results of a Longitudinal Continuation Study
- 1 January 2002
- journal article
- clinical trial
- Published by Oncology Nursing Society (ONS) in Oncology Nursing Forum
- Vol. 29 (1), 33-40
- https://doi.org/10.1188/02.onf.33-40
Abstract
To evaluate the intermediate term efficacy and toxicity of the use of venlafaxine for the control of hot flashes. An open-label continuation phase study following a double-blind, randomized, placebo-controlled clinical trial that tested three doses of venlafaxine for the control of hot flashes. North Central Cancer Treatment Group institutions. 102 postmenopausal women. Women could titrate venlafaxine to optimum efficacy while recording daily hot flash counts and weekly toxicity information. Hot flash frequency, hot flash score. The reduction in hot flashes previously reported in the randomized study phase was maintained during the open-label study. Toxicity did not appear to increase over time. The data from this study provides evidence that venlafaxine has intermediate term efficacy and good tolerability as a treatment for hot flashes. Nurses can inform symptomatic women that an effective nonhormonal alternative exists to control their hot flashes.Keywords
This publication has 16 references indexed in Scilit:
- Venlafaxine in management of hot flashes in survivors of breast cancer: a randomised controlled trialThe Lancet, 2000
- SNaRIs, NaSSAs, and NaRIs: new agents for the treatment of depressionThe Lancet, 2000
- The menopauseThe Lancet, 1999
- Definitions of Hot Flashes in Breast Cancer SurvivorsJournal of Pain and Symptom Management, 1998
- Prospective evaluation of vitamin E for hot flashes in breast cancer survivors.Journal of Clinical Oncology, 1998
- A cohort study of hormone replacement therapy given to women previously treated for breast cancer.Climacteric, 1998
- Menopause: a problem for breast cancer patientsEuropean Journal of Cancer Care, 1995
- Megestrol Acetate for the Prevention of Hot FlashesNew England Journal of Medicine, 1994
- Transdermal clonidine for ameliorating tamoxifen-induced hot flashes.Journal of Clinical Oncology, 1994
- Effect of Bellergal Retard on climacteric complaints: a double-blind, placebo-controlled studyMaturitas, 1987