Low-grade gliomas: The debate continues

Abstract

Low-grade gliomas (LGG) are a heterogeneous group of tumors that tend to occur primarily in young adults and children. They are indolent, progressive, and often undergo anaplastic transformation. The prognosis of these tumors is primarily affected by age and pathologic type. Many questions remain in the management of LGGs, including the role of surgical resection (ie, maximal tumor resection), the optimal timing of radiation (ie, postoperative vs at the time of tumor progression), and the role of chemotherapy (ie, salvage after radiotherapy, primary treatment after surgery, concurrent with radiotherapy). Further complicating treatment decisions are concerns about toxicity with any intervention because LGG patients can often lead a relatively normal existence for years with no intervention. In this article we review the pertinent LGG literature published over the past few years and its impact on the management of LGGs.