How Do Cells Sense Oxygen?
- 20 April 2001
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 292 (5516), 449-451
- https://doi.org/10.1126/science.1060849
Abstract
How do organisms sense the amount of oxygen in the environment and respond appropriately when the amount of oxygen decreases (a condition called hypoxia)? In their Perspective, Zhu and Bunn discuss new findings ( Ivan et al., Jaakkola et al.) that reveal how the HIF transcription factor, which switches on a group of hypoxia-response proteins, is itself regulated by changes in oxygen tension.Keywords
This publication has 17 references indexed in Scilit:
- Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl HydroxylationScience, 2001
- The von Hippel–Lindau tumor suppressor proteinCurrent Opinion in Genetics & Development, 2001
- Mechanism of regulation of the hypoxia-inducible factor-1alpha by the von Hippel-Lindau tumor suppressor proteinThe EMBO Journal, 2000
- Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor ProteinPublished by Elsevier BV ,2000
- Identification of a cytochrome b -type NAD(P)H oxidoreductase ubiquitously expressed in human cellsProceedings of the National Academy of Sciences of the United States of America, 1999
- Regulation of Mammalian O2Homeostasis by Hypoxia-Inducible Factor 1Annual Review of Cell and Developmental Biology, 1999
- Characterization of an Oxygen/Redox-Dependent Degradation Domain of Hypoxia-Inducible Factor α (HIF-α) ProteinsBiochemical and Biophysical Research Communications, 1999
- Regulation of hypoxia-inducible factor 1α is mediated by an O 2 -dependent degradation domain via the ubiquitin-proteasome pathwayProceedings of the National Academy of Sciences of the United States of America, 1998
- A haemoprotein with kinase activity encoded by the oxygen sensor of Rhizobium melilotiNature, 1991
- Regulation of the Erythropoietin Gene: Evidence That the Oxygen Sensor Is a Heme ProteinScience, 1988