Cross-over trials inStatistics in Medicine: the first ‘25’ years
Open Access
- 6 September 2006
- journal article
- research article
- Published by Wiley in Statistics in Medicine
- Vol. 25 (20), 3430-3442
- https://doi.org/10.1002/sim.2706
Abstract
Papers on cross-over trials that have appeared in the first 25 years of Statistics in Medicine are reviewed. Papers on bioequivalence are also considered. After a brief statistical summary, individual papers are discussed under seven headings: 1. The two-stage analysis of AB/BA trials, 2. Baselines, 3. Binary and categorical data, 4. Survival data, 5. Modelling carry-over, 6. Bioequivalence and 7. Components of variation. Finally, a brief assessment of the importance in this field of Statistics in Medicine is given. Copyright © 2006 John Wiley & Sons, Ltd.Keywords
This publication has 45 references indexed in Scilit:
- Individual Therapy: New Dawn or False Dawn?Drug Information Journal, 2001
- THE CASE FOR CROSS‐OVER TRIALS IN PHASE IIIStatistics in Medicine, 1995
- Bioequivalence Evaluation—Possible Future DevelopmentsClinical Research and Regulatory Affairs, 1994
- On population and individual bioequivalenceStatistics in Medicine, 1993
- An overview of methods for the analysis of longitudinal dataStatistics in Medicine, 1992
- Is the ‘simple carry‐over’ model useful?Statistics in Medicine, 1992
- Consideration of individual bioequivalenceJournal of Pharmacokinetics and Biopharmaceutics, 1990
- The analysis of data from 2 × 2 cross‐over trials with baseline measurementsStatistics in Medicine, 1987
- A Log-Linear Model for Binary Cross-Over DataJournal of the Royal Statistical Society Series C: Applied Statistics, 1987
- An exact test for comparing matched proportions in crossover designsBiometrika, 1969