Pathogenesis of Classical and Lymphocyte-Predominant Hodgkin Lymphoma
- 1 February 2009
- journal article
- review article
- Published by Annual Reviews in Annual review of pathology
- Vol. 4 (1), 151-174
- https://doi.org/10.1146/annurev.pathol.4.110807.092209
Abstract
Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (HL) and lymphocytic and histiocytic (L&H) cells in nodular lymphocyte–predominant HL (NLPHL) are derived from germinal-center B cells. HRS cells have, however, largely lost their B cell phenotype and aberrantly express markers and transcriptional regulators of other hematolymphoid cell types. Deregulation of multiple signaling pathways and downstream transcription factors, including receptor tyrosine kinases, nuclear factor–kappa B (NF-κB), and Janus kinase/signal transducer and activator of transcription (JAK/STAT), is a further hallmark of HRS cells. These cells harbor genetic lesions that contribute to or cause increases in the activity of transcription factors of the NF-κB and STAT families. HRS cells are found within a mixed reactive cellular infiltrate and interact with these nonmalignant cells in a complex fashion that appears to be essential for HRS cell survival and proliferation. Less is known about the pathogenesis of L&H cells in NLPHL, but increases in the activity of receptor tyrosine kinases, NF-κB, and JAK/STAT have also been detected.Keywords
This publication has 138 references indexed in Scilit:
- Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysisThe Journal of Experimental Medicine, 2008
- Expression of CCR5 receptors on Reed–Sternberg cells and Hodgkin lymphoma cell lines: Involvement of CCL5/Rantes in tumor cell growth and microenvironmental interactionsInternational Journal of Cancer, 2007
- The AP1-dependent secretion of galectin-1 by Reed–Sternberg cells fosters immune privilege in classical Hodgkin lymphomaProceedings of the National Academy of Sciences of the United States of America, 2007
- Gains of REL in primary mediastinal B‐cell lymphoma coincide with nuclear accumulation of REL proteinGenes, Chromosomes and Cancer, 2007
- Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-κB activationNature, 2006
- Patterned CpG Methylation of Silenced B Cell Gene Promoters in Classical Hodgkin Lymphoma-derived and Primary Effusion Lymphoma Cell LinesJournal of Molecular Biology, 2005
- Differential expression of activation‐induced cytidine deaminase (AID) in nodular lymphocyte‐predominant and classical Hodgkin lymphomaThe Journal of Pathology, 2005
- De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signallingNature, 2004
- Unique Polycomb Gene Expression Pattern in Hodgkin's Lymphoma and Hodgkin's Lymphoma-Derived Cell LinesThe American Journal of Pathology, 2004
- Formation of multinucleated cells in a Hodgkin's‐disease‐derived cell lineInternational Journal of Cancer, 1989