Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis.
Open Access
- 1 August 1985
- Vol. 26 (8), 822-824
- https://doi.org/10.1136/gut.26.8.822
Abstract
A double blind controlled trial has been conducted in 40 patients to compare the therapeutic effects of prednisolone metasulphobenzoate enemas with those of prednisolone-21-phosphate enemas. Both enemas brought about improvement in symptoms and sigmoidoscopic appearances in more than 70% of patients treated. The absorption of prednisolone from the metasulphobenzoate enema in three patients was less than from the 21-phosphate enema. In view of the low plasma prednisolone concentrations obtained, there are theoretical advantages in using a poorly absorbed enema to avoid the possibility of systemic steroid effects in patients requiring long term steroid treatment.This publication has 5 references indexed in Scilit:
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