Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth

Abstract

Objective Prevalence of type 1 diabetes (T1D) disease is increasing worldwide. We aim to test correlation of T1D prevalence to the reduced natural selection measured by Biological State Index (I_bs). Research design and methods Country-specific estimates of T1D prevalence, life expectancy, obesity prevalence rate, urbanization rates, per capita sugars consumption and per capita gross domestic product (GDP) were obtained. I_bs and country-specific longevity (e₅₀) increase for each country were self-calculated. These data were then matched to T1D prevalence by country for our ecological study among 118 countries. Countries were also grouped to study the associations in different regions. SPSS V.22 was used for correlation analysis. Results Worldwide, both I_bs and life expectancy at birth (I_bs proxy) were significantly correlated to T1D prevalence in Pearson r (r=0.713, p_bs (r=0.307, pbs exponentially correlated to T1D prevalence. Pearson correlations generally existed in different country categorizations by geographic region, culture background and economic status. Conclusions Reduced natural selection may have contributed to the increasing T1D prevalence worldwide. T1D epidemiology study in total population may be the practical solution to identify the causes of increasing T1D prevalence.