Hypothalamic ERK Mediates the Anorectic and Thermogenic Sympathetic Effects of Leptin
Open Access
- 1 March 2009
- journal article
- Published by American Diabetes Association in Diabetes
- Vol. 58 (3), 536-542
- https://doi.org/10.2337/db08-0822
Abstract
OBJECTIVE—Leptin is an adipocyte hormone that plays a major role in energy balance. Leptin receptors in the hypothalamus are known to signal via distinct mechanisms, including signal transducer and activator of transcription-3 (STAT3) and phosphoinositol-3 kinase (PI 3-kinase). Here, we tested the hypothesis that extracellular signal–regulated kinase (ERK) is mediating leptin action in the hypothalamus.Keywords
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