Detection of Aldehydes and Their Conjugated Hydroperox Ydiene Precursors in Thermally-Stressed Culinary Oils and Fats: Investigations Using High Resolution Proton Nmr Spectroscopy
- 1 January 1995
- journal article
- research article
- Published by Informa UK Limited in Free Radical Research
- Vol. 22 (5), 441-482
- https://doi.org/10.3109/10715769509147552
Abstract
High field (400 and 600 MHz) proton NMR spectroscopy has been employed to investigate the thermally-induced autoxidation of glycerol-bound polyunsaturated fatty acids present in intact culinary frying oils and fats. Heating of these materials at 180°C for periods of 30, 60 and 90 min. generated a variety of peroxidation products, notably aldehydes (alkanals, trans-2-alkenals and alka-2, 4-dienals) and their conjugated hydroperoxydiene precursors. Since such aldehydes appear to be absorbed into the systemic circulation from the gut in vivo, the toxicological significance of their production during standard frying practices is discussed.Keywords
This publication has 59 references indexed in Scilit:
- Toxicity of dietary lipid peroxidation productsTrends in Food Science & Technology, 1990
- Cytotoxicities of a linoleic acid hydroperoxide and its related aliphatic aldehydes toward cultured human umbilical vein endothelial cellsChemico-Biological Interactions, 1988
- Aliphatic aldehydes inhibit the proliferative response of human peripheral blood lymphocytes to phytohemagglutinin and alloantigensChemico-Biological Interactions, 1987
- Lipid peroxidation and molecular damage to polyunsaturated fatty acids in rat liver. Recognition of two classes of hydroperoxides formed under conditions in vivoChemico-Biological Interactions, 1986
- Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, A possible alkenal metabolite of the alkaloids, and related alkenalsToxicology and Applied Pharmacology, 1986
- Chemotactic Activity of the Lipid Peroxidation Product 4-Hydroxynonenal and Homologous HydroxyalkenalsBiological Chemistry Hoppe-Seyler, 1986
- Effects of 4-hydroxynonenal on adenylate cyclase and 5′-nucleotidase activities in rat liver plasma membranesChemico-Biological Interactions, 1985
- Inhibition by reactive aldehydes of superoxide anion radical production in stimulated human neutrophilsChemico-Biological Interactions, 1985
- Identification of 4-hydroxynonenal as a cytotoxic product originating from the peroxidation of liver microsomal lipidsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1980
- Mechanisms of lipid peroxide formation in tissues Role of metals and haematin proteins in the catalysis of the oxidation of unsaturated fatty acidsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965