Role of frontal versus temporal cortex in verbal fluency as revealed by voxel-based lesion symptom mapping
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- 1 July 2006
- journal article
- research article
- Published by Cambridge University Press (CUP) in Journal of the International Neuropsychological Society
- Vol. 12 (06), 896-900
- https://doi.org/10.1017/s1355617706061078
Abstract
Category and letter fluency tasks have been used to demonstrate psychological and neurological dissociations between semantic and phonological aspects of word retrieval. Some previous neuroimaging and lesion studies have suggested that category fluency (semantic-based word retrieval) is mediated primarily by temporal cortex, while letter fluency (letter-based word retrieval) is mediated primarily by frontal cortex. Other studies have suggested that both letter and category fluency are mediated by frontal cortex. We tested these hypotheses using voxel-based lesion symptom mapping (VLSM) in a group of 48 left-hemisphere stroke patients. VLSM maps revealed that category and letter fluency deficits correlate with lesions in temporal and frontal cortices, respectively. Other regions, including parietal cortex, were significantly implicated in both tasks. Our findings are therefore consistent with the hypothesis that temporal cortex subserves word retrieval constrained by semantics, whereas frontal regions are more critical for strategic word retrieval constrained by phonology. (JINS, 2006, 12, 896–900.)Keywords
This publication has 17 references indexed in Scilit:
- Pervasive influence of semantics in letter and category fluency: A multidimensional approachBrain and Language, 2003
- A Functional Magnetic Resonance Imaging Study of Overt Letter Verbal Fluency Using a Clustered Acquisition Sequence: Greater Anterior Cingulate Activation with Increased Task DemandNeuroImage, 2002
- Distinct patterns of word retrieval in right and left frontal lobe patients: a multidimensional perspectiveNeuropsychologia, 2001
- Clustering and switching on verbal fluency: the effects of focal frontal- and temporal-lobe lesionsNeuropsychologia, 1998
- Letter and category fluency in patients with frontal lobe lesions.Neuropsychology, 1998
- The role of working memory capacity in retrieval.Journal of Experimental Psychology: General, 1997
- A new brain region for coordinating speech articulationNature, 1996
- Generating ‘tiger’ as an animal name or a word beginning with T: differences in brain activationProceedings Of The Royal Society B-Biological Sciences, 1996
- A comparison of category and letter fluency in Alzheimer's disease and Huntington's disease.Neuropsychology, 1994
- The assessment and analysis of handedness: The Edinburgh inventoryNeuropsychologia, 1971