Effect of vitamin E on aminotransferase levels and insulin resistance in children with non‐alcoholic fatty liver disease
- 28 November 2006
- journal article
- research article
- Published by Wiley in Alimentary Pharmacology & Therapeutics
- Vol. 24 (11-12), 1553-1561
- https://doi.org/10.1111/j.1365-2036.2006.03161.x
Abstract
Few data are available on the effect of antioxidants in paediatric non-alcoholic fatty liver disease (NAFLD). To compare the effect of a nutritional programme alone or combined with alpha-tocopherol and ascorbic acid on alanine aminotransferase (ALT) levels, and insulin resistance (IR) in biopsy-proven NAFLD children. IN a 12-month double-blind placebo study, 90 patients were prescribed a balanced calorie diet (25-30 cal/kg/d), physical exercise, and placebo (group A) or alpha-tocopherol 600 IU/day plus ascorbic acid 500 mg/day (group B). IR was estimated by the homeostasis model assessment (HOMA-IR). At month 12, ALT (32.67 +/- 8.09 vs. 32.18 +/- 11.39 IU/L; P = NS), HOMA-IR (1.52 +/- 0.66 vs. 1.84 +/- 0.95 IU/L; P = NS), and weight loss (32% vs. 35% of excessive body weight; P = NS) did not differ between the two arms. Among subjects who lost >or=20% of their excessive weight, ALT and body weight percentage changes were significantly related (r(o) = 0.260; P = 0.03). In subjects, who lost more than 1.0 kg, HOMA-IR significantly decreased (2.20 +/- 0.21 to 1.57 +/- 0.13 in group A (P <or= 0.01; -8%); 2.91 +/- 0.24 to 1.88 +/- 0.16 in group B (-32%; P <or= 0.0001)). ALT decreased by 36% (59.13 +/- 4.11 vs. 30.27 +/- 1.46 IU/L; P <or= 0.001), and 42% (68.19 +/- 5.68 vs. 31.92 +/- 1.92 IU/L; P <or= 0.0001). In a multivariate analysis, fasting insulin changes in group A (P = 0.012; F = 7.150). Diet and physical exercise in NAFLD children seem to lead to a significant improvement of liver function and glucose metabolism beyond any antioxidant therapy.Keywords
This publication has 41 references indexed in Scilit:
- Design and validation of a histological scoring system for nonalcoholic fatty liver diseaseHepatology, 2005
- Effect of weight reduction on liver histology and biochemistry in patients with chronic hepatitis CGut, 2002
- Non‐antioxidant molecular functions of α‐tocopherol (vitamin E)FEBS Letters, 2002
- Interaction between 4-Hydroxy-2,3-alkenals and the Platelet-derived Growth Factor-β ReceptorPublished by Elsevier BV ,2000
- Vitamin E treatment of nonalcoholic steatohepatitis in children: A pilot studyThe Journal of Pediatrics, 2000
- Comparison of serum concentrations of α-tocopherol and β-carotene in a cross-sectional sample of obese and nonobese children (NHANES III)The Journal of Pediatrics, 1999
- Alcoholic liver disease: dose and threshold—new thoughts on an old topicGut, 1997
- Evidence That the Rat Hepatic Mitochondrial Carrier Is Distinct from the Sinusoidal and Canalicular Transporters for Reduced GlutathioneJournal of Biological Chemistry, 1995
- Persistent hyperaminotransferasemia resolving after weight reduction in obese childrenThe Journal of Pediatrics, 1994
- Fatty Liver and Its Fibrous Changes Found in Simple Obesity of ChildrenJournal of Pediatric Gastroenterology and Nutrition, 1984