Association between High Levels of Expression of the TRK Gene and Favorable Outcome in Human Neuroblastoma
- 25 March 1993
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 328 (12), 847-854
- https://doi.org/10.1056/nejm199303253281205
Abstract
The nerve growth factor receptor is expressed in some neuroblastomas, in which its primary component is encoded by the TRK proto-oncogene. To determine the relation of the expression of TRK messenger RNA in neuroblastomas to other clinical and laboratory variables, we studied frozen tumor samples from 77 patients. In addition, we tested two primary neuroblastomas that expressed TRK for responsiveness to nerve growth factor.Keywords
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