The Role of Atg Proteins in Autophagosome Formation
Top Cited Papers
- 10 November 2011
- journal article
- review article
- Published by Annual Reviews in Annual Review of Cell and Developmental Biology
- Vol. 27 (1), 107-132
- https://doi.org/10.1146/annurev-cellbio-092910-154005
Abstract
Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically regulated by starvation and other stresses and involves complicated membrane reorganization. Since the discovery of yeast Atg-related proteins, autophagosome formation has been dissected at the molecular level. In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.Keywords
This publication has 100 references indexed in Scilit:
- Protein misfolding disorders and macroautophagyCurrent Opinion in Cell Biology, 2011
- Chaperone-mediated autophagy in protein quality controlCurrent Opinion in Cell Biology, 2011
- RalB and the Exocyst Mediate the Cellular Starvation Response by Direct Activation of Autophagosome AssemblyCell, 2011
- ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell DeathCell, 2010
- Mitochondria Supply Membranes for Autophagosome Biogenesis during StarvationCell, 2010
- Role of autophagy in suppression of inflammation and cancerCurrent Opinion in Cell Biology, 2010
- The role of the Atg1/ULK1 complex in autophagy regulationCurrent Opinion in Cell Biology, 2010
- Methods in Mammalian Autophagy ResearchCell, 2010
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- Selective degradation of mitochondria by mitophagyArchives of Biochemistry and Biophysics, 2007