BCL‐2 expression in adult and embryonic non‐haematopoietic tissues
- 1 April 1993
- journal article
- research article
- Published by Wiley in The Journal of Pathology
- Vol. 169 (4), 431-437
- https://doi.org/10.1002/path.1711690408
Abstract
The B-cell leukaemia/lymphoma-2 (bcl-2) proto-oncogene is unusual as its product appears to provide survival advantage to B cells by blocking apoptosis. In this study, the expression of bcl-2 has been examined in normal nonhaematopoietic tissues, embryos, and psoriatic skin by immunohistochemical staining. Bcl-2 protein expression is mainly observed in cell populations with a long life and/or proliferating ability such as duct cells in exocrine glands, basal keratinocytes, cells at the bottom of colon crypts, and neurons. In the skin of both adult and embryo and also embryonic kidney and cartilage, bcl-2 expression was observed in cells which were undergoing morphological transition from undifferentiated stem cells to committed precursor cells. The finding of bcl-2 expression in the terminal differentiated syncytial trophoblast, but not cytotrophoblast, and in some cells responsive to hormone stimulation such as in the endometrium and myometrium suggests that the gene expression may be related too hormone responsiveness. As no bci-2 localization was seen in the benign hyperproliferative skin condition psoriasis, this does not suggest a straightforward link to proliferation. These observations support the view that the bcl-2 gene may have an important role in cell development, maturation, and the path to terminal differentiation.This publication has 11 references indexed in Scilit:
- Bcl-2 maintains B cell memoryNature, 1991
- BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death.Proceedings of the National Academy of Sciences of the United States of America, 1991
- Induction of bcl-2 expression by epstein-barr virus latent membrane protein 1 protects infected B cells from programmed cell deathCell, 1991
- Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell deathNature, 1990
- Bcl-2: B Cell Life, Death and NeoplasiaCurrent Topics in Microbiology and Immunology, 1990
- Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells.JCI Insight, 1987
- Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.Proceedings of the National Academy of Sciences of the United States of America, 1985
- Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18Cell, 1985
- Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome TranslocationScience, 1984
- Atrophy and apoptosis in the cyclical human endometriumThe Journal of Pathology, 1976