Cerebral amyloid deposition and diffuse plaques in ``normal'' aging

Abstract
Arguments have been raised, however, against A beta deposition as the critical event in AD pathogenesis. [9] One argument is that many apparently nondemented individuals have appreciable numbers of A beta-containing SPs in cerebral cortex. [10,11] In particular, the presence in cerebral cortex of diffuse SPs (amorphous or fibrillar deposits of A …

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