Effect of caffeine on self‐sustained firing in human motor units
- 1 December 2002
- journal article
- clinical trial
- Published by Wiley in The Journal of Physiology
- Vol. 545 (2), 671-679
- https://doi.org/10.1113/jphysiol.2002.025064
Abstract
This study examined the effect of caffeine on self-sustained firing (SSF) of human motor units. At physiological doses, caffeine acts as a competitive antagonist to the inhibitory effects of adenosine. This antagonism has many possible effects on the central nervous system. One of these effects is to increase the release of the excitatory neurotransmitters serotonin and noradrenaline. In addition, caffeine increases serotonin concentration in brainstem regions that have excitatory projections to spinal motor neurons. Since plateau potentials, which are responsible for SSF, are facilitated by these neurotransmitters, we hypothesized that caffeine would increase the frequency at which SSF occurs. A double-blind, repeated-measures design using either drug (6 mg kg(-1) caffeine) or placebo (flour) was carried out on seven male subjects who reported ingesting less than 200 mg week(-1) caffeine. We investigated the occurrence of SSF in tibialis anterior motor units (214 trials) and found a significant (P < 0.05) increase in the occurrence of SSF in the caffeine trial (87.0 +/- 5.8 %) compared to the placebo (64.6 +/- 9.7 %). These data further verify the presence of SSF in the tibialis anterior motor units of young men and provide indirect evidence of the facilitation of plateau potentials by monoamines in the human neuromuscular system.This publication has 47 references indexed in Scilit:
- Adenosine, Adenosine Receptors and the Actions of Caffeine *Basic & Clinical Pharmacology & Toxicology, 1995
- Motor neuron ‘bistability’: A pathogenetic mechanism for cramps and myokymiaBrain, 1994
- Caffeine and Exercise: Metabolism and PerformanceCanadian Journal of Applied Physiology, 1994
- Cerebrospinal Fluid Concentrations of Caffeine Following Oral Drug AdministrationTherapeutic Drug Monitoring, 1994
- Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effectsBrain Research Reviews, 1992
- Plateau potentials and active integration in the ‘final common pathway’ for motor behaviourTrends in Neurosciences, 1991
- Effect of intravenous aminophylline on plasma levels of catecholamines and related cardiovascular and metabolic responses in man.Circulation, 1983
- Effects of adenosine and adenine nucleotides on synaptic transmission in the cerebral cortexCanadian Journal of Physiology and Pharmacology, 1979
- Prolonged activation of soleus motoneurones following a conditioning train in soleus Ia afferents — A case for a reverberating loop?Neuroscience Letters, 1975
- Relation between Size of Neurons and Their Susceptibility to DischargeScience, 1957