Topical, single dose bisphosphonate treatment reduced bone resorption in a rat model for prosthetic loosening
Open Access
- 1 March 2004
- journal article
- Published by Wiley in Journal of Orthopaedic Research
- Vol. 22 (2), 244-249
- https://doi.org/10.1016/j.orthres.2003.08.008
Abstract
Fluid pressure, instability or particles have been suggested to cause peri‐prosthetic bone resorption. High intracapsular pressures have been reported in hip joints with loose prosthetic components, and oscillating fluid pressure has been shown to cause dramatic bone resorption in animal models. Resorption can be reduced by systemic bisphosphonate treatment in rat models with oscillating fluid pressure, but this has required higher doses than needed to inhibit normal remodelling. Bisphosphonates have high affinity to bone mineral. Topical application of the drug is therefore feasible. We used a previously described rat model where oscillating fluid pressure causes bone resorption. Before pressurization, a 1 mg/ml solution of alendronate was applied onto the bone surface for 1 min, after which excess bisphosphonate was rinsed away. Bone resorption was measured on histological slides as soft tissue area at the interface. Rats treated with topical alendronate had soft tissue areas reduced by half. Topical bisphosphonate treatment before cementing a joint implant could possibly reduce the risk of later loosening. © 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.Keywords
This publication has 18 references indexed in Scilit:
- Bone allografts pretreated with a bisphosphonate are not resorbedActa Orthopaedica, 2002
- Reduction of instability-induced bone resorption using bisphosphonates: High doses are needed in ratsActa Orthopaedica, 2002
- Pressure‐induced periprosthetic osteolysis: A rat modelJournal of Orthopaedic Research, 2000
- Clodronate prevents prosthetic migration: A randomized radiostereometric study of 50 total knee patientsActa Orthopaedica, 2000
- Qualitative Analysis of Peripheral Peri-Implant Bone and Influence of Alendronate Sodium on Early Bone RegenerationThe Journal of Periodontology, 1999
- Disposition of Alendronate Following Local Delivery in a Rat JawThe Journal of Periodontology, 1999
- Inhibition of Wear Debris Mediated Osteolysis in a Canine Total Hip Arthroplasty ModelPublished by Ovid Technologies (Wolters Kluwer Health) ,1997
- Local Delivery of an Amino Bisphosphonate Prevents the Resorptive Phase of Alveolar Bone Following Mucoperiosteal Flap Surgery in RatsThe Journal of Periodontology, 1997
- Influential factors in cemented acetabular cup looseningThe Journal of Arthroplasty, 1992
- Bisphosphonate action. Alendronate localization in rat bone and effects on osteoclast ultrastructure.JCI Insight, 1991